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Broccoli-Based Medicine – A Potent Tool Against Osteoarthritis and Cancer

February 6, 2015 By Sherri

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Story at-a-glance+

By Dr. Mercola – September 9, 2013

Science has proven time and again that Mother Nature is the best physician, and food is the best medicine. Broccoli, for example—and to an even greater degree, broccoli sprouts—have been repeatedly shown to be one of nature’s most valuable health-promoting foods, capable of preventing a number of health issues, including but not limited to:

  • Hypertension1
  • Allergies2
  • Diabetes3
  • Osteoarthritis4, 5
  • Cancer

How Broccoli Can Help Slow Progression of Arthritis

What is Broccoli Good For?  For starters, it can help with arthritis.  Most recently, the benefits of broccoli for the prevention and treatment of the most common form of arthritis has made headlines. As reported by BBC News6:

“Eating lots of broccoli may slow down and even prevent osteoarthritis, according to a team of researchers at the University of East Anglia who are starting human trials following on from successful lab studies.7

Tests on cells and mice showed that a broccoli compound, sulforaphane – which humans can also get from Brussels sprouts and cabbage – blocked a key destructive enzyme that damages cartilage.”

According to lead researcher Ian Clark, the results are “very promising,” as they’ve now shown that sulforaphane works in each of the three laboratory models they’ve tried so far—in human and cow cartilage cells, tissue, and live mice.

Sulforaphane, which is known for its anti-inflammatory and anti-cancer benefits, can also be found in other cruciferous vegetables, such as Brussels sprouts, cauliflower and cabbage.

Broccoli, however, is one of the richest sources of this potent compound, and broccoli sprouts appear to be one of the richest sources of all. The compound also has anti-diabetic and antimicrobial activity. According to Clark:8

“As well as treating those who already have [osteoarthritis], you need to be able to tell healthy people how to protect their joints into the future. There is currently no way in to the disease pharmaceutically and you cannot give healthy people drugs unnecessarily, so this is where diet could be a safe alternative. Prevention would be preferable and changes to lifestyle, like diet, may be the only way to do that.”

The Anti-Cancer Properties of Broccoli

Sulforaphane, a sulfur compound, has also been shown to kill cancer stem cells, thereby slowing tumor growth. Some researchers believe eliminating cancer stem cells may be key to controlling cancer.

This is something current chemotherapies cannot do, but food can! I have long touted the cancer busting power of broccoli; ever since studies in the mid-1990s showed that the broccoli compoundglucoraphanin — a precursor to sulforaphane – boosts cell enzymes that protect against molecular damage from cancer-causing chemicals.9, 10

Studies have also found that sulforaphane normalizes DNA methylation11—a process by which a methyl group (one carbon atom attached to three hydrogen atoms) is added to part of a DNA molecule. DNA methylation is a crucial part of normal cell function, allowing cells to “remember who they are and where they have been” and is important in regulating gene expression.

DNA methylation also suppresses the genes for things you don’t want, such as viral and other disease-related genes, and abnormal DNA methylation plays a critical role in the development of nearly all types of cancer.

The sulforaphane from broccoli plays a role in activating more than 200 different genes. Specifically, it appears that broccoli contains the necessary ingredients to switch ON genes that prevent cancer development, and switch OFF other ones that help it spread. And you don’t have to consume a truckload of broccoli to reap its benefits.

In fact, a 2008 study published in PLoS One12 found that just four servings of broccoli per week could protect men from prostate cancer. One serving of broccoli is about two spears, so that’s only 10 broccoli spears per week. In this study, the researchers collected tissue samples over the course of the study and found that the men who ate broccoli showed hundreds of beneficial changes in genes known to play a role in fighting cancer.

Sulforaphane Works on a Wide Variety of Cancers

Other researchers have looked at sulforaphane’s effect on breast cancer, and discovered that it hinders the growth of human breast cancer cells as well—at least in the laboratory. Here, they found that it does so by disrupting the action of protein microtubules within the cancer cells, which promote cell division and growth. Interestingly enough, certain cancer drugs also work in this manner. The upside of broccoli, of course, is that it doesn’t come with ANY of the side effects associated with synthetic drugs. Furthermore, as reported by PreventDisease.com13:

“Previous research has also proven that the compound blocks the formation of breast tumors in rats, and it can even force colon cancer cells to commit cell suicide. It seems that sulforaphane works its magic on the detoxification enzymes that try to defend the cancer-promoting substances.”

The interesting aspect of chemoprotection strategies is that they’re almost never organ-specific. Rather, chemoprotection produces a general cancer protective effect which blocks multiple steps — a cascade of steps — that are common to cancer formation. This is probably a reason why broccoli appears to work against a variety of different types of cancers.

Sprouts—An Even More Potent Alternative

As stated earlier, about 10 broccoli spears per week has been shown to offer protection against prostate cancer, which isn’t a whole lot, but research14 has shown that fresh broccoli sprouts are FAR more potent, allowing you to eat far less in terms of quantity. This is also an excellent alternative if you don’t like the taste (or smell) of broccoli. In terms of research, even small quantities of broccoli sprout extracts have been shown to markedly reduce the size of rat mammary tumors that were induced by chemical carcinogens. According to researchers at Johns Hopkins University15:

“Three-day-old broccoli sprouts consistently contain 20 to 50 times the amount of chemoprotective compounds found in mature broccoli heads, and may offer a simple, dietary means of chemically reducing cancer risk.”

When compared to either broccoli or cauliflower, which also contains sulforaphane,16 three-day-old broccoli sprouts contain anywhere from 10 to 100 times higher levels of glucoraphanin, compared to the mature varieties. Best of all, you can grow broccoli sprouts at home quite easily and inexpensively. Another major benefit is that you don’t have to cook them. They are eaten raw, usually as an addition to salad.

Furthermore, if you opt for mature broccoli heads, it becomes more important to make sure you’re purchasing a variety of high potency.17 In tests, the chemoprotective abilities of samples from 22 varieties of fresh and seven brands of frozen mature broccoli varied greatly. Fresh broccoli sprouts, on the other hand, are far more uniform in their potency.

Interestingly, researchers have found that an extract of broccoli sprouts helps protect your skin from sun damage, which could potentially lead to skin cancer. According to Dr. Paul Talalay, a professor of pharmacology and molecular sciences at Johns Hopkins University School of Medicine in Baltimore:18

“Cells contain an elaborate network of protective genes that code for proteins that protect against four principal injurious processes to which all of our cells are exposed and which are the causes of cancer, degenerative disease and aging. Those four processes are: oxidation; DNA damage; inflammation and radiation, namely ultraviolet radiation. The cells’ protective system normally operates at about one-third capacity, so the real question is what would ramp up that system.

The highest doses of sulforaphane extract reduced UV-induced redness and inflammation (erythema) by an average of 37 percent, although protection varied from 8 percent to 78 percent. If you apply an extract of broccoli sprouts that contains high levels of sulforaphane to regions of human skin, you can protect them very substantially.“[Emphasis mine]

How to Grow Your Own Broccoli Sprouts

Broccoli sprouts look and taste similar to alfalfa sprouts, and are easily grown at home, even if you’re limited on space. I strongly recommend using organic seeds, and a pound of seeds will probably make over 10 pounds of sprouts. From the researcher’s calculations mentioned earlier, this can translate up to as much cancer protecting phytochemicals as 1,000 pounds (half a ton) of broccoli!

I used to grow sprouts in Ball jars over 10 years ago but stopped doing that. I am strongly convinced that actually growing them in soil is far easier and produces far more nutritious and abundant food. It is also less time consuming. With Ball jars, you need to rinse them several times a day to prevent mold growth. Trays also take up less space. I am now consuming one whole tray of sprouts every 2-3 days and to produce that much food with Ball jars I would need dozens of jars. I simply don’t have the time or patience for that. You can find instructions on how to grow sprouts by viewing a step-by-step guide at rawfoods-livingfoods.com.

Your Diet Can Be a Powerful Cancer Prevention Tool

There’s little doubt that one of the best ways to improve your health is to make sure you’re eating plenty of fresh, organic vegetables, ideally locally-grown, with a majority of them consumed raw. Two of the easiest and most efficient ways to optimize your vegetable intake is to juice your vegetables and add sprouted seeds. Sprouting is undoubtedly one of the best ways to increase the nutritional content of your diet, as the sprouting process tends to increase nutrient content and bioavailability of those nutrients.

Sprouts—which again are eaten raw—also contain valuable enzymes that allow your body to absorb and use the nutrients of all other foods you eat as well. Some sprouts, like sunflower seeds, have up to 30 times the nutrient density of even home grown organic vegetables. I personally consume about 4-6 ounces of sunflower seed sprouts every day that I either grow at home or our team does in our office.

Juicing is another great way to get a wider variety of veggies into your diet, and will help your body absorb all the nutrients from the vegetables by making them easily digestible. You’re also avoiding the risk of damaging any of their sensitive micronutrients through cooking, which destroys many micronutrients by altering their shape and chemical composition. For more in-depth guidelines and information about juicing, I recommend you review the juicing section of my nutrition plan.

My Recommended Vegetables List provides a guide to the most nutritious vegetables and those to limit due to their high carbohydrate content. Broccoli is certainly on the most nutritious list, but so are many others like celery, Bok Choy and beet greens. Remember, variety is key. So while broccoli and broccoli sprouts are the focus of this article, they should be part of a wide variety of vegetables and legumes in your diet. There are many other foods that contain other cancer-protective nutrients and compounds, as well as so-called anti-angiogenetic foods, which effectively help “starve” cancer by preventing blood vessels from forming to feed microscopic tumors in the first place:

Green tea Berries: strawberries, blackberries, raspberries, blueberries Cherries
Red grapes Kale Turmeric
Nutmeg Artichokes Parsley
Garlic Tomato Maitake mushroom

Fermented veggies are another outstanding superfood. But whatever method you choose; juiced, whole, sprouted, cooked or fermented, do make it a point to eat your veggies. This is one food group that is incredibly diverse, so there’s a wide variety to choose from and plenty to suit virtually everyone’s tastes. And, as you can see, mounting evidence shows that eating vegetables every day is a cornerstone of good health, and a habit that can go a very long way toward preventing disease of all kinds, including cancer.

Filed Under: Thoughts for the Day Tagged With: allergies, anti-inflammatory, arthritis, artichoke, berries, broccoli, broccoli sprouts, cancer, cancer stem cells, cherries, diabetes, fermented vegetables, garlic, green tea, hypertension, kale, maitake mushroom, nutmeg, osteoarthritis, parsley, red grapes, sulforaphane, tumors

Magnesium: An Invisible Deficiency That Could Be Harming Your Health

January 23, 2015 By Sherri

Magnesium: An Invisible Deficiency That Could Be Harming Your Health

Magnesium Deficiency

Story at-a-glance+

By Dr. Mercola

Magnesium is a mineral used by every organ in your body, especially your heart, muscles, and kidneys.1 If you suffer from unexplained fatigue or weakness, abnormal heart rhythms or even muscle spasms and eye twitches, low levels of magnesium could be to blame.

If you’ve recently had a blood test, you might assume it would show a magnesium deficiency. But only 1 percent of magnesium in your body is distributed in your blood, making a simple sample of magnesium from a serum magnesium blood test not very useful.

Most magnesium is stored in your bones and organs, where it is used for many biological functions. Yet, it’s quite possible to be deficient and not know it, which is why magnesium deficiency has been dubbed the “invisible deficiency.”

By some estimates, up to 80 percent of Americans are not getting enough magnesium and may be deficient. Other research shows only about 25 percent of US adults are getting the recommended daily amount of 310 to 320 milligrams (mg) for women and 400 to 420 for men.2

Even more concerning, consuming even this amount is “just enough to ward off outright deficiency,” according to Dr. Carolyn Dean, a medical and naturopathic doctor.

Magnesium Deficiency May Trigger 22 Medical Conditions

 

Download Interview Transcript

Magnesium is often thought of primarily as a mineral for your heart and bones, but this is misleading. Researchers have now detected 3,751 magnesium-binding sites on human proteins, indicating that its role in human health and disease may have been vastly underestimated.3

Magnesium is also found in more than 300 different enzymes in your body and plays a role in your body’s detoxification processes, making it important for helping to prevent damage from environmental chemicals, heavy metals, and other toxins. In addition, magnesium is necessary for:

  • Activating muscles and nerves
  • Creating energy in your body by activating adenosine triphosphate (ATP)
  • Helping digest proteins, carbohydrates, and fats
  • Serving as a building block for RNA and DNA synthesis
  • Acting as a precursor for neurotransmitters like serotonin

Dr. Dean has studied and written about magnesium for more than 15 years. The latest addition of her book, The Magnesium Miracle, came out in 2014 and in it you can learn about 22 medical areas that magnesium deficiency triggers or causes, all of which have all been scientifically proven. This includes:4

Anxiety and panic attacks Asthma Blood clots
Bowel diseases Cystitis Depression
Detoxification Diabetes Fatigue
Heart disease Hypertension Hypoglycemia
Insomnia Kidney disease Liver disease
Migraine Musculoskeletal conditions (fibromyalgia, cramps, chronic back pain, etc.) Nerve problems
Obstetrics and gynecology (PMS, infertility, and preeclampsia) Osteoporosis Raynaud’s syndrome
Tooth decay

Early signs of magnesium deficiency include loss of appetite, headache, nausea, fatigue, and weakness. An ongoing magnesium deficiency can lead to more serious symptoms, including:

Numbness and tingling Muscle contractions and cramps Seizures
Personality changes Abnormal heart rhythms Coronary spasms

The Role of Magnesium in Diabetes, Cancer, and More

Most people do not think about magnesium when they think about how to prevent chronic disease, but it plays an essential role. For instance, there have been several significant studies about magnesium’s role in keeping your metabolism running efficiently—specifically in terms of insulin sensitivity, glucose regulation, and protection from type 2 diabetes.

Higher magnesium intake reduces risk of impaired glucose and insulin metabolism and slows progression from pre-diabetes to diabetes in middle-aged Americans.5Researchers stated, “Magnesium intake may be particularly beneficial in offsetting your risk of developing diabetes, if you are high risk.”

Multiple studies have also shown that higher magnesium intake is associated with a higher bone mineral density in both men and women,6 and research from Norway has even found an association between magnesium in drinking water and a lower risk of hip fractures.7

Magnesium may even help lower your risk of cancer, and a study published in theAmerican Journal of Clinical Nutrition showed that higher intakes of dietary magnesium were associated with a lower risk of colorectal tumors.8

Results from the meta-analysis indicated that for every 100-mg increase in magnesium intake, the risk of colorectal tumor decreased by 13 percent, while the risk of colorectal cancer was lowered by 12 percent. The researchers noted magnesium’s anti-cancer effects may be related to its ability to reduce insulin resistance, which may positively affect the development of tumors.

Surprising Factors That Influence Your Magnesium Levels

Seaweed and green leafy vegetables like spinach and Swiss chard can be excellent sources of magnesium, as are some beans, nuts, and seeds, like pumpkin, sunflower, and sesame seeds. Avocados also contain magnesium. Juicing your vegetables is an excellent option to ensure you’re getting enough of them in your diet.

However, most foods grown today are deficient in magnesium and other minerals, so getting enough isn’t simply a matter of eating magnesium-rich foods (although this isimportant too). According to Dr. Dean:

“Magnesium is farmed out of the soil much more than calcium… A hundred years ago, we would get maybe 500 milligrams of magnesium in an ordinary diet. Now we’re lucky to get 200 milligrams.”

Herbicides, like glyphosate also act as chelators, effectively blocking the uptake and utilization of minerals in so many foods grown today. As a result, it can be quite difficult to find truly magnesium-rich foods. Cooking and processing further depletes magnesium.

Meanwhile, certain foods can actually influence your body’s absorption of magnesium. If you drink alcohol in excess, for instance, it may interfere with your body’s absorption of vitamin D, which in turn is helpful for magnesium absorption. If you eat a lot of sugar, this can also cause your body to excrete magnesium through your kidneys, “resulting in a net loss,” according to Dr. Danine Fruge, associate medical director at the Pritikin Longevity Center in Florida.9 The following factors are also associated with lower magnesium levels:10

  • Excessive intake of soda or caffeine
  • Menopause
  • Older age (older adults are more likely to be magnesium deficient because absorption decreases with age and the elderly are more likely to take medications that can interfere with absorption)
  • Certain medications, including diuretics, certain antibiotics (such as gentamicin and tobramycin), corticosteroids (prednisone or Deltasone), antacids, and insulin
  • An unhealthy digestive system, which impairs your body’s ability to absorb magnesium (Crohn’s disease, leaky gut, etc.)

Calcium, Vitamin K2, and Vitamin D Must Be Balanced with Magnesium

It may seem like you could remedy the risks of low magnesium simply by taking a supplement, but it’s not quite that simple. When you’re taking magnesium, you need to consider calcium, vitamin D3 and vitamin K2 as well, since these all work synergistically with one another. Excessive amounts of calcium without the counterbalance of magnesium can lead to a heart attack and sudden death, for instance. Research on the Paleolithic or caveman diet has shown that the ratio of calcium to magnesium in the diet that our bodies evolved to eat is 1-to-1.11Americans in general tend to have a higher calcium-to-magnesium ratio in their diet, averaging about 3.5-to-1.

If you have too much calcium and not enough magnesium, your muscles will tend to go into spasm, and this has consequences for your heart in particular. “What happens is, the muscle and nerve function that magnesium is responsible for is diminished. If you don’t have enough magnesium, your muscles go into spasm. Calcium causes muscle to contract. If you had a balance, the muscles would do their thing. They’d relax, contract, and create their activity,” Dr. Dean explains.

When balancing calcium and magnesium, also keep in mind that vitamins K2 and D need to be considered. These four nutrients perform an intricate dance together, with one supporting the other. Lack of balance between these nutrients is one of the reasons why calcium supplements have become associated with increased risk of heart attacks and stroke, and why some people experience vitamin D toxicity. Part of the explanation for these adverse side effects is that vitamin K2 keeps calcium in its appropriate place. If you’re K2 deficient, added calcium can cause more problems than it solves, by accumulating in the wrong places, like your soft tissue.

Similarly, if you opt for oral vitamin D, you need to also consume it in your food or take supplemental vitamin K2 and more magnesium. Taking mega doses of vitamin D supplements without sufficient amounts of K2 and magnesium can lead to vitamin D toxicity and magnesium deficiency symptoms, which include inappropriate calcification that may damage your heart.

Tips for Increasing Your Magnesium Levels

One way to really increase your magnesium, as well as many other important plant-based nutrients, is by juicing your greens. I typically drink one pint to one quart of fresh green vegetable juice every day, and this is one of my primary sources of magnesium. Organic foods may have more magnesium if grown in nutrient-rich soils but it is very difficult to make that determination. If you opt for a supplement, be aware that there are a wide variety of magnesium supplements on the market, because magnesium must be bound to another substance. There’s simply no such thing as a 100 percent magnesium supplement.

The substance used in any given compound can affect the absorption and bioavailability of the magnesium, and may provide slightly different, or targeted, health benefits. The table that follows summarizes some of the differences between the various forms. Magnesium threonate and citrate are some of the best sources, as it seems to penetrate cell membranes, including your mitochondria, which results in higher energy levels. Additionally, it also penetrates your blood-brain barrier and seems to do wonders to treat and prevent dementia and improve memory. If you take a supplement, you can use the “bowel test” to determine if you’re taking too much magnesium. Dr. Dean explains:12

“The best way to tell if you are getting enough magnesium is the “bowel test”. You know when you have too much magnesium when your stools become loose. This, in fact, may be a blessing for people with constipation… [which] is one of the many ways magnesium deficiency manifests.”

Besides taking a supplement, another way to improve your magnesium status is to take regular Epsom salt baths or foot baths. Epsom salt is a magnesium sulfate that can absorb into your body through your skin. Magnesium oil can also be used for topical application and absorption. Whatever supplement you choose, be sure to avoid any containing magnesium stearate, a common but potentially hazardous additive.

Magnesium glycinate is a chelated form of magnesium that tends to provide the highest levels of absorption and bioavailability and is typically considered ideal for those who are trying to correct a deficiency. Magnesium oxide is a non-chelated type of magnesium, bound to an organic acid or a fatty acid. Contains 60 percent magnesium, and has stool softening properties
Magnesium chloride/Magnesium lactate contain only 12 percent magnesium, but has better absorption than others, such as magnesium oxide, which contains five times more magnesium Magnesium sulfate/Magnesium hydroxide (milk of magnesia) are typically used as laxatives. Be aware that it’s easy to overdose on these, so ONLY take as directed
Magnesium carbonate, which has antacid properties, contains 45 percent magnesium Magnesium taurate contains a combination of magnesium and taurine, an amino acid. Together, they tend to provide a calming effect on your body and mind
Magnesium citrate is magnesium with citric acid, which like most magnesium supplements has laxative properties but is well absorbed and cost effective Magnesium threonate is a newer, emerging type of magnesium supplement that appears promising, primarily due to its superior ability to penetrate the mitochondrial membrane, and may be the best magnesium supplement on the market

 

Filed Under: Uncategorized Tagged With: asthma, ATP, back pain, blood clots, bowel, calcium, carbohydrates, coronary, depression, detoxification, diabetes, DNA, Dr. Mercola, energy, fatigue, fats, fibromyalgia, heart, hypertension, hypoglycemia, insomnia, kidney, liver, magnesium, migraine, muscles, nerves, neurotrasmitters, numbness, nutrition, nutrition deficiency, osteoporosis, protein, RNA, seizures, serotonin, tingline, tooth decay, vitamin d, vitamin k2

About Me

About Me

I am a singer, dancer, actress, model. ... Oh wait! That was my life BEFORE Lyme Disease, Multiple Sclerosis, Traumatic Brain Injury and Chemical Injury. Join me on my pursuit to find joy in the midst of loss and pain! The one thing I certainly still have in this life is my humor! I hope you enjoy my blog full of information about living with disabling illness, pain and loss, as well as counting my blessings and just being plain silly!

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